Monderma- 18 Jun 2025
- Support collagen renewal
- Hydrate and refine texture
- Soothe inflammation gently
- Improve tone and resilience
- Personalised skincare with Monderma
Regenerative skincare appeals to those seeking smoother, hydrated skin, especially as natural renewal slows with age. Advances in active ingredients now provide supportive ways to enhance texture [1,8].
In this article we explore how peptides and polynucleotides function within skincare, highlighting their roles in hydration, regeneration, and skin comfort across a range of concerns.
Understanding Peptides For Skin
Peptides help form collagen and elastin, which keep the skin firm and supple. Ageing reduces natural protein production, leading to visible fine lines and gradual loss of elasticity [1,8].
Peptides may support barrier strength and hydration. Their signalling activity can help the skin maintain resilience and smoother tone, while also contributing to comfort by easing minor irritation [1,8].
Peptide Functions & Benefits
| Feature | Role Or Benefit |
|---|---|
| Protein Foundation | Collagen and elastin synthesis |
| Hydration Support | Maintains moisture retention |
| Barrier Repair | Helps reinforce the skin surface |
| Regeneration Signal | May guide renewal processes |
Table 1: Key functions of peptides
Role Of Polynucleotides In Skincare
Polynucleotides act as biostimulators, encouraging hydration, comfort, and cellular balance. They interact with tissue at a restorative level and may support elasticity and smoother texture [2 to 7].
These ingredients attract water, helping refine tone. Their soothing activity can be beneficial for delicate areas or persistent redness. Evidence suggests they may also support improvement in scarring and pigmentation [2 to 7].
Benefits Of Polynucleotide Treatment
| Benefit | Evidence Or Mechanism |
|---|---|
| Collagen And Elasticity | Fibroblast activation |
| Hydration | Attracts and binds water |
| Texture And Tone | Surface refinement |
| Inflammation Modulating | Helps ease visible redness |
Table 2: Core benefits of polynucleotides
Integrating Regenerative Formulas
Peptides and polynucleotides fit comfortably into routines designed to support ageing skin or texture changes. They complement established practices that focus on gentle cleansing and moisture balance [1,2,8].
Serums allow concentrated delivery of actives, while moisturisers help seal hydration. Regular sunscreen supports skin integrity and reduces external stressors that may affect results over time [8].
Routine Steps & Purpose
| Step | Purpose |
|---|---|
| Cleanser | Lifts impurities and prepares the skin |
| Toner | Balances pH and primes absorption |
| Serum | Delivers focused active ingredients |
| Moisturiser | Supports hydration and comfort |
| Sunscreen | Protects from UV related ageing |
Table 3: Routine overview
Choosing Suitable Products
Peptide or polynucleotide skincare varies in strength, so selecting stable formulations supports consistency [1,2]. Combining them with ingredients like niacinamide or hyaluronic acid may enhance hydration or barrier support [1,8].
Those exploring more advanced options, such as injectable polynucleotides, may benefit from clinical assessment to guide safe and appropriate use [1,2,6].

Future Of Regenerative Care
Research continues to refine how regenerative actives are delivered, encouraging personalised approaches that consider sustainability and ingredient efficiency [1,2,4,5].
| Trend | Description |
|---|---|
| Personalised Skincare | Tailored to genetics or skin profile |
| Sustainable Ingredients | Sourced with environmental awareness |
| Delivery Systems | Designed for enhanced penetration |
Table 4: Emerging trends
Conclusion
Monderma offers personalised prescription skincare that targets concerns such as ageing, hyperpigmentation, and inflammation using clinically supported ingredients like peptides and polynucleotides. Each formula is tailored to your skin type and needs for optimal care.
If you would like personalised skincare designed to strengthen and maintain skin resilience, you can explore a tailored formula through Monderma.
Content is for informational purposes only. Monderma treatments are prescribed following consultation. Results and timeframes can vary. Use as directed by your prescriber.
References
- Clin Cosmet Investig Dermatol. Synthetic peptides
- Cosmedics Skin Clinics. Polynucleotide treatments
- Ashleigh Todd. Regenerative treatments
- Dr Horlick. Polynucleotide biostimulators
- London Dermatology Centre. Polynucleotide research
- Healthline. Peptides for skin
- Additional regenerative research







