Niacinamide is a vitamin B3–derived antioxidant that helps strengthen the skin barrier, lock in moisture, and support smoother, more supple skin.
First identified in the 1930s and approved for UK use in the 1990s, niacinamide has become a cornerstone of dermatology’s focus on preventative care and long-term skin health.
Get your niacinamide formula in 3 simple steps with Monderma:
a short, secure consultation
your monthly niacinamide prescription
with progress – cancel, restart anytime
Shipped in a vegan base with hydrating hyaluronic acid and peptides, your blend may also include up to 2 other active ingredients, namely adapalene, azelaic acid, clindamycin, hydroquinone, ivermectin, or tretinoin.
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VS | Retail |
|---|---|---|
| Prescription Antioxidant | Retinol | |
| 3-in-1 Active Treatment | 3 Separate Creams | |
| Personalised To Your Skin | One-Size-Fits-All | |
| Up To 20x Stronger Results | Limited Efficacy | |
| Pharmacist Led | Retail | |
| Dermatological | Cosmetic | |
Monderma niacinamide formulas are prescribed and dispensed by GPhC-registered prescribers and pharmacists, ensuring safe and clinically guided use.
While results vary, many patients notice stronger skin, improved hydration, and a smoother-looking complexion after consistent use. Some may experience temporary tingling, dryness, or redness as the skin adjusts.
My skin is looking great and is very happy!
Packaging is very luxurious and the cream itself is a lovely consistency which absorbs in to the skin.
Skin feels clearer already!
Really good product to use and excellent results within a few weeks so far.
Amazing custom skin formulae high quality and value
It’s been about 3 months since I’ve been using Monderma, and I can say I’ve seen transformative results on my face.
Help strengthen the skin barrier, lock in moisture, and support a smoother-looking complexion with a niacinamide formula.
Shop now to save 25% and enjoy free shipping with Monderma – limited time only.
Monderma's niacinamide is typically applied to your face. It can also be used on your neck and under-eye area with moisturiser. A low strength is recommended for these areas, as they are more sensitive. Avoid applying it too close to your eyelids.
Apply TWO pumps to clean, dry skin on the affected area(s) once daily at NIGHT. After application, wash your hands and follow up with applying a moisturiser. Use a sunscreen of SPF30 or higher daily to protect your skin.
Monderma prescribes niacinamide in strengths ranging from 2% to 4%, within the national guidelines.
The most suitable strength for you varies based on several factors, including whether it is acne, ageing skin, hyperpigmentation, or rosacea being treated, prior use of antioxidants, and individual skin response. Starting too high or increasing strength too quickly can lead to skin irritation.
While some users gradually increase their strength, the majority find that maintaining a consistent, lower concentration provides optimal results for their skin.
You may start to see visible results after 1 week. However, for lasting results, we recommend nightly use for at least 12 weeks.
In most cases, niacinamide is a safe and reliable ingredient for long-term use.
Although niacinamide is designed to treat skin conditions, some users may experience mild side effects. This includes peeling, tingling, and redness, particularly during the initial adjustment period.
To minimise this risk, Monderma recommends starting with a lower strength and applying a moisturiser to support your skin as it adapts.
Niacinamide is generally considered safe for use during pregnancy.
Niacinamide is generally safe to combine with most over-the-counter skincare products.