Niacinamide For Refined Pores
Niacinamide is a vitamin B3–derived antioxidant used to help strengthen the skin barrier, support moisture retention, and promote supple-looking skin.
First identified in the 1930s and approved for UK use in the 1990s, niacinamide is a cornerstone ingredient in preventative dermatology and long-term skin resilience.
How It Works
Improve surface-level concerns in 3 steps
Complete
your quick and secure consultation
Begin
your niacinamide prescription plan
Adjust
your strength as your skin improves
Inside Your Niacinamide Cream
Made in a gentle vegan base, your niacinamide cream may include other active ingredients, carefully selected from adapalene, azelaic acid, ectoine, clindamycin, hydroquinone, ivermectin, tranexamic acid, and tretinoin.
GPhC Registered Pharmacy
MHRA Approved Suppliers
Dermatologically Tested
Money Back Guarantee
Recyclable
Vegan Friendly
Cruelty Free
Fragrance Free
Alcohol Free
Paraben Free
Sulfate Free
Gluten Free
Micronised
Highly Spreadable
Non Comedogenic
The Monderma Difference
 |
VS | Over The Counter |
|---|---|---|
| Topical Treatment | Retail Skincare | |
| Dermatological Lightener | Cosmetic Retinol | |
| Multiple Products | Triple Active Blend | |
| Personalised Strengths | One-Size-Fits-All | |
| Up To 20× Higher Efficacy | Limited Visible Change | |
Guided Results You Can Trust
Monderma’s niacinamide formulas are overseen by GPhC-registered prescribers and pharmacists for safe, guided use.
As your skin adjusts over time, your prescriber can review and modify the strength or frequency to ensure the treatment remains suitable.
Real Experiences, Genuine Confidence
My skin is looking great and is very happy
Packaging is very luxurious and the cream itself is a lovely consistency which absorbs in to the skin.
– Loli, UK
Skin feels clearer already
Really good product to use and excellent results within a few weeks so far.
– Sadie, UK
Personalised niacinamide creams compounded to strengthen the skin barrier, support moisture balance, and promote more supple-looking skin.
Update your routine with prescriber-led recommendations today.
Your Questions, Answered With Care
Niacinamide is usually applied to the face, and can also be used on the neck and under-eye area when paired with a moisturiser. These areas tend to be more delicate, so a lower strength is generally recommended. Avoid applying it too close to the eyelids for comfort and safety.
Apply TWO pumps to clean, dry skin on the affected area(s) once daily at NIGHT. After applying, wash your hands and follow with a moisturiser to support comfort and hydration. Use an SPF 30 or higher every morning to keep your skin protected throughout treatment.
Monderma prescribes niacinamide in strengths starting from 2% up to a maximum of 4%.
The right strength for you depends on several factors, including whether you are treating acne, wrinkles, hyperpigmentation, or rosacea, your previous experience with lightening agents, and how your skin naturally responds. Starting too high or increasing too quickly can lead to unnecessary irritation.
Although some users gradually adjust their strength over time, many find that a consistent, lower strength provides the most comfortable experience and the most reliable long-term results.
You may begin to notice early visible improvements after the first week. For more sustained and meaningful results, nightly use for at least 12 weeks is recommended.
For most users, niacinamide is a well-tolerated and reliable option for long-term skincare when used as directed.
Although niacinamide is effective for a range of skin concerns, some users may experience mild side effects as their skin adjusts. These can include peeling, redness, or sensitivity, particularly during the first few weeks.
To minimise this, Monderma recommends beginning with a lower strength and pairing your treatment with a moisturiser to help maintain comfort as your skin adapts.
Niacinamide is generally considered safe for use during pregnancy.
Niacinamide is generally safe to use alongside most over-the-counter skincare products. If you are using any additional prescription skincare, you must inform Monderma so your niacinamide formula can be reviewed for safe continued use.
Please also inform any healthcare professional or treatment provider about your prescription skincare. Certain procedures may require pausing niacinamide before and after treatment to minimise sensitivity and reduce the risk of adverse reactions.