Ingredient Trends: Exosomes, PDRN & Postbiotics Explained

Interest in advanced ingredients continues to grow as people explore new options for skin comfort and resilience across different skin types and ages.

In this article, we outline how exosomes, PDRN, postbiotics, and adaptogens are being studied, and how these ingredients may fit into supportive skincare routines.

Understanding Exosomes

Exosomes are tiny vesicles that carry proteins and signals between cells, and early studies suggest they may support repair and surface hydration [1,2].

Researchers note potential calming effects and changes in elasticity, though evidence in cosmetic use remains limited at this stage [2].

Exosomes & Skin Features

Table 1: Exosome related features

Understanding PDRN

PDRN is a DNA derived ingredient studied for tissue repair and wound recovery, and evidence shows activity in supporting regeneration pathways [3].

Most research focuses on impaired skin rather than healthy cosmetic skin, and findings continue to develop across different study groups [3,5,6].

PDRN & Regeneration

Table 2: PDRN related features

Understanding Postbiotics

Postbiotics are non living metabolites formed during fermentation, and early research suggests they may support barrier strength and balanced hydration [4,8].

Their stability makes them suitable for daily formulations, though studies in broader groups are still developing [8].

Postbiotic Features

Table 3: Postbiotic related features

Understanding Adaptogens

Adaptogens such as ginseng and ashwagandha are studied for their antioxidant and calming activity, and may support resilience to daily environmental stress [9,10].

Evidence is still emerging, and most research remains early stage or based on preclinical findings [9,10].

Adaptogen Features

Table 4: Adaptogen related features

Using These Ingredients

These ingredients may complement routine skincare, though evidence is strongest for repair in impaired skin rather than cosmetic use [2,3,8].

Choices should be made with care, and patch testing can help assess individual comfort with new formulations.

Monderma Support For Skin Concerns

Monderma provides personalised prescription skincare for acne, ageing skin, hyperpigmentation, and rosacea, using ingredients such as tretinoin, azelaic acid, and niacinamide.

These formulations support long term skin comfort and clarity, offering a structured approach that complements general skincare trends.

Conclusion

Emerging ingredients such as exosomes, PDRN, postbiotics, and adaptogens show promise in early research, though most data remain exploratory.

Readers seeking tailored guidance can explore options through our guided skin consultation, which offers personalised care for long term skin health.

Content is for informational purposes only. Monderma treatments are prescribed following consultation. Results and timeframes can vary. Use as directed by your prescriber.

References

1. Lee Y, El Andaloussi S, Wood MJA. Exosomes And Microvesicles
2. Najafabadi AH, Yazdanpanah Z, Garousi Mokhtarzadeh D, et al. Exosomes In Skin Photoaging
3. Bitto A, Polito F, Altavilla D, et al. Pharmacological Activity And Clinical Use Of PDRN
4. Rawal S, Nath L, Kaur S, et al. Probiotics And Postbiotics
5. Colangelo MT, Galli C, Guizzardi S. Polydeoxyribonucleotide And Tissue Regeneration
6. Galeano M, Pallio G, Irrera N, et al. Polydeoxyribonucleotide In Wound Healing
7. Lee SH, Kim J, Sung JH, Jung J. PDRN And Skin Regeneration
8. Rawal S, Nath L, Kaur S, et al. Dermal Health And Postbiotics
9. Liu XX, Zhang JY, Xie JY, et al. Adaptogens In Dermatology
10. Liu XX, et al. Adaptogen Mechanisms In Skin Support