Benefits Of Benzoyl Peroxide & Azelaic Acid For Acne

Benzoyl peroxide and azelaic acid are well known ingredients for acne prone skin, offering support for people who want clearer and more even looking skin [1,2,3].

This article explains how each ingredient works, how they complement each other, and how to use them safely within a routine that protects comfort and clarity [1,4].

Understanding These Ingredients

Benzoyl peroxide delivers oxygen into pores, creating an environment that reduces growth of acne related bacteria while supporting exfoliation of surface build up [1].

Studies show that regular use of benzoyl peroxide can reduce inflammatory acne lesions by thirty to fifty five percent within twelve weeks of consistent routine use [1,4].

Azelaic acid supports gentle exfoliation, reduces visible redness, and helps fade post inflammatory hyperpigmentation, making it helpful for sensitive skin [2].

A clinical review found that a twenty percent azelaic acid cream can perform similarly to a five percent benzoyl peroxide preparation for mild or moderate acne [2].

Can They Be Used Together

Using benzoyl peroxide and azelaic acid together can offer wider support by combining antibacterial action with gentle exfoliation and calming effects [1,2,4].

Careful introduction helps reduce temporary dryness, which some people experience when starting active ingredients for acne prone or sensitive skin [5,6].

Starting A Safe Routine

A patch test helps ensure that both ingredients are well tolerated, especially for people with skin that becomes reactive or red when trying new skincare.

A gradual approach supports comfort, such as using a lower strength of benzoyl peroxide or applying both ingredients on alternate days early in the routine [1].

Barrier Support & Hydration

Both ingredients can cause some dryness at first, which makes moisturising an important step to maintain comfort and protect the skin barrier [5].

Using a non comedogenic moisturiser with hydrating ingredients supports routine tolerance and may reduce visible flaking as the skin adjusts [6].

Benefits Of This Combination

Table 1: Benefits of combined use

Body Acne Support

These ingredients can also support areas such as the back or chest, where pores may clog more easily due to sweat and friction from clothing or exercise.

Applying a thin layer after cleansing may help reduce new breakouts, especially when paired with regular moisturising to reduce dryness.

Routine Structure

A simple structure may include cleansing, hydrating toner, azelaic acid, benzoyl peroxide for targeted areas, moisturiser, and sunscreen in morning routines [7].

Using sunscreen daily supports protection, since some people may notice mild increased sensitivity with benzoyl peroxide when exposed to sunlight [7].

Potential Side Effects

Dryness or mild redness can occur when beginning these ingredients, especially in the first weeks of use, and can improve with moisturiser support [5].

If irritation persists, reducing frequency or adjusting product strength can help maintain comfort while still supporting acne reduction goals [7].

Monderma Skin Support

Monderma provides personalised prescription skincare for acne, hyperpigmentation, rosacea, and wrinkles, with formulas prepared by trained prescribers.

Ingredients such as azelaic acid and niacinamide may be included to support clarity, texture, and brightness through tailored daily application [6].

Conclusion

Benzoyl peroxide and azelaic acid offer complementary support for acne by reducing bacteria, easing clogged pores, and helping fade uneven tone [1,2].

A calm, gradual approach helps maintain comfort while building a routine that supports clearer and more even looking skin with long term consistency [4,6].

To explore a routine designed for your skin, you can begin with our personalised skincare consultation.

Content is for informational purposes only. Monderma treatments are prescribed following consultation. Results and timeframes can vary. Use as directed by your prescriber.

References

1. NICE. Acne vulgaris management. NG198.
2. Iraji F, Sadeghinia A, Shahmoradi Z, et al. Efficacy of topical azelaic acid. Indian J Dermatol Venereol Leprol. 2007.
3. Clinical Approaches in Vogue for Combination Therapies for Acne and PIH. Cosmoderma. 2025.
4. AAFPOGé LK, et al. Acne vulgaris diagnosis and treatment. American Family Physician. 2019.
5. NHS. Side effects of benzoyl peroxide.
6. Marques C, et al. Niacinamide in skin health. Frontiers in Pharmacology. 2024.
7. Typology. Is benzoyl peroxide a photosensitising substance. 2025.