Niacinamide is a vitamin B3–derived antioxidant used to help strengthen the skin barrier, support moisture retention, and promote supple-looking skin.
First identified in the 1930s and approved for UK use in the 1990s, niacinamide is a cornerstone ingredient in preventative dermatology and long-term skin resilience.
your quick and secure consultation
your niacinamide prescription plan
your formula as your skin improves
Made in a gentle vegan base cream, your niacinamide formula may include other active ingredients, selected from adapalene, azelaic acid, clindamycin, hydroquinone, ivermectin, and tretinoin.
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VS | Retail |
|---|---|---|
| Prescription Antioxidant | Cosmetic Retinol Only | |
| 3-in-1 Active Treatment | 3 Separate Products Needed | |
| Personalised To Your Skin | One-Size-Fits-All | |
| Up To 20× Higher Efficacy | Limited Visible Change | |
| Care From UK-Registered Pharmacists | Standard Retail Product | |
| Dermatology-Grade Standards | Non-Clinical Standards | |
Monderma’s niacinamide formulas are overseen by GPhC-registered prescribers and pharmacists for safe, guided use.
As your skin adjusts over time, your prescriber can review and modify the strength or frequency to ensure the treatment remains suitable.
My skin is looking great and is very happy!
Packaging is very luxurious and the cream itself is a lovely consistency which absorbs in to the skin.
Skin feels clearer already!
Really good product to use and excellent results within a few weeks so far.
Amazing custom skin formulae high quality and value
It’s been about 3 months since I’ve been using Monderma, and I can say I’ve seen transformative results on my face.
Personalised niacinamide formulas compounded to strengthen the skin barrier, support moisture balance, and promote smoother, more supple-looking skin.
Update your routine with prescriber-led recommendations today.
Monderma's niacinamide is typically applied to your face. It can also be used on your neck and under-eye area with moisturiser. A low strength is recommended for these areas, as they are more sensitive. Avoid applying it too close to your eyelids.
Apply TWO pumps to clean, dry skin on the affected area(s) once daily at NIGHT. After application, wash your hands and follow up with applying a moisturiser. Use a sunscreen of SPF30 or higher daily to protect your skin.
Monderma prescribes niacinamide in strengths ranging from 2% to 4%, within the national guidelines.
The most suitable strength for you varies based on several factors, including whether it is acne, ageing skin, hyperpigmentation, or rosacea being treated, prior use of antioxidants, and individual skin response. Starting too high or increasing strength too quickly can lead to skin irritation.
While some users gradually increase their strength, the majority find that maintaining a consistent, lower concentration provides optimal results for their skin.
You may start to see visible results after 1 week. However, for lasting results, we recommend nightly use for at least 12 weeks.
In most cases, niacinamide is a safe and reliable ingredient for long-term use.
Although niacinamide is designed to treat skin conditions, some users may experience mild side effects. This includes peeling, tingling, and redness, particularly during the initial adjustment period.
To minimise this risk, Monderma recommends starting with a lower strength and applying a moisturiser to support your skin as it adapts.
Niacinamide is generally considered safe for use during pregnancy.
Niacinamide is generally safe to combine with most over-the-counter skincare products.