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![Noticing Midlife Change?](/wp-content/uploads/2024/11/Middle-aged-caucasian-woman-after-ageing-skin-treatment.jpg" "Noticing Midlife Change?")
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Noticing Midlife Change?
The skin begins to age at the age of 25, often disproportionately between the ages of 35 and 55, resulting in a dull complexion.
Yet 80% of it is preventable.
How It Works?
Renew ageing skin in 3 simple steps with Monderma:
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Get your monthly ageing skin formula
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What's In Your Nightly Cream?
Delivered in a vegan base of hyaluronic acid and peptides, your personalised blend contains up to 3 dermatological actives, designed for optimal efficacy.
Recyclable
Vegan Friendly
Cruelty Free
Fragrance Free
Alcohol Free
GPhC Regulated Pharmacy
MHRA Approved Suppliers
Dermatologically Tested
Pharmacist Led
The Monderma Difference
| Retail | VS |  |
|---|---|---|
| Up To 3 Creams | All In One Multitasker | |
| Batch Produced | Personalised | |
| Over The Counter | Pharmacist Led | |
| Cosmetic Ingredients | Dermatological actives | |
| Lower Efficacy | Micronised | |
| Limited Strength | Up To 20x Strength | |
| Not Regulated | GPhC Regulated | |
| Self Assessment | MHRA Suppliers | |
Maximum Ageing Skin Results
Ageing skin formulas are supplied by GPhC registered prescribers and pharmacists for safe, effective use.
Individual results differ, but you will typically notice fewer fine lines and age spots. Mild side effects such as peeling, tingling, and redness may initially occur as your skin adjusts.
Tried, Tested, Loved: Hear It Firsthand
For the price point I really recommend them. Personable and thumbs up from me
“It definitely works as I can feel my skin feeling firmer and tighter, and have had a few people say my skin looks glowing!”
– Anand P, Middlesex, UK
I was expecting something this advanced to cost three times as much
“The fine wrinkles and sun damage are less noticeable, and my skin feels more youthful.”
– Julie T, Ceredigion, UK
Smooth fine lines, minimise wrinkles, and tone age spots decisively.
Get 50% off and enjoy free shipping with Monderma today—limited time only.
Still Have Questions?
Ageing skin starts around age 25 and accelerates in the 40's and 70's.
Women’s skin often intrinsically ages faster, while men are more affected by extrinsic factors.
Lighter skin tones tend to show wrinkles more visibly, while darker skin tones develop more hyperpigmentation.
Visible symptoms of ageing skin include fine lines and wrinkles, hyperpigmentation, thinning and loss of volume, and dry skin.
The face and neck show the most signs of ageing. It also affects the arms and legs more than other parts of the body.
Ageing skin occurs through dual mechanisms:
| Subtype | Description | Common Areas |
|---|---|---|
| Intrinsic Ageing (chronological) | Normal course of ageing, closely linked to the biological clock and the passage of time | Entire body |
| Extrinsic Ageing (photoageing) | Premature ageing caused by external factors, which accelerates intrinsic ageing | Face, neck, arms, and legs |
Up to 80% of ageing skin symptoms are attributed to extrinsic factors.
While intrinsic ageing cannot be prevented, reducing extrinsic ageing is becoming increasingly possible.
Ageing skin is caused by the skin’s decline in collagen and elastin production.
This happens because:
| Cause | Description |
|---|---|
| Genetics | Genetics determine the rate at which cells replicate, repair, and respond to stress, with some mutations or variations accelerating cellular breakdown |
| Cellular | Collagen provides structure and elasticity to the skin and decreases by 1% per year after the age of 25, while elastin fibres, which help the skin return to its original shape after stretching, also diminish |
| Hormones | Hormones, particularly oestrogen and testosterone, decline with age, reducing skin moisture |
The extrinsic factors that accelerate ageing skin include:
| Contributor | Description |
|---|---|
| Photoageing | Photoageing occurs when ultraviolet (UV) radiation from sunlight and tanning beds alters DNA, accelerating the breakdown of collagen and elastin fibres |
| Nutrition | Nutrition including diets high in sugar and processed foods cause glycation, stiffening collagen and reducing flexibility |
| Medications | Medications including immunosuppressants and stress-related drugs weaken cell resilience and accelerate cellular damage |
| Smoking | Smoking, particularly nicotine, constricts blood vessels, reducing blood flow and limiting the oxygen and nutrient supply to skin cells |
| Alcohol | Alcohol, when consumed excessively, dehydrates the skin, depleting it of essential moisture and nutrients |
| Cosmetics | Cosmetics becomes important as the natural exfoliation process slows down with age, for example infrequent cleansing leads to dead skin cells, oil, and dirt buildup |
| Environment | Environment impacts like pollution and smoke, harsh working conditions, and chronic stress can have an adverse effect on hormonal levels and skin health |
Understanding these extrinsic factors, especially sun exposure, is crucial for preventing premature ageing skin.
Monderma’s GPhC-registered prescribers assess ageing skin through a visual examination using uploaded images or a virtual consultation.
This examination assesses your face and neck, determining symptoms and characteristics for severity, duration, and progression. Your medical history is taken into account.
The normal course of ageing includes:
| Age | Distribution | Characteristics |
|---|---|---|
| 25-30 | <10% | Early signs like fine lines, slight collagen loss, minimal visible ageing |
| 30's | 10-20% | Fine lines deepen, mild sagging begins, first sun spots appear |
| 40's | 20-40% | Wrinkles become more pronounced, skin loses elasticity, pigmentation increases |
| 50's | 40-60% | Deeper wrinkles, hormonal changes cause significant loss of firmness |
| 60's | 60-80% | Skin thins noticeably, sagging and dryness increase, age spots become prominent |
| Over 70 | >80% | Deeply wrinkled, skin becomes fragile, and loses fat and elasticity |
Ageing skin is a cosmetic concern but may signal underlying health issues, such as nutritional deficiency or hormonal imbalance.
If over-the-counter skincare has been ineffective or your skin is at risk of complications, Monderma may supply a personalised treatment plan.
Monderma’s GPhC-registered prescribers design a monthly ageing skin formula, compounded by our GPhC-registered pharmacy. Your formula is adjusted based on your feedback, ensuring it remains safe and effective.
Ingredients and their strengths are dermatologically approved, with up to 3 of the following included:
| Ingredient | Properties |
|---|---|
| Retinoid | Speeds up skin cell renewal to shrink pores, clear spots, and smooth fine lines |
| Lightening Agent | Reduces melanin to lighten patches of darker skin |
| Anti-Inflammatory | Blocks irritable molecules to reduce redness, calm inflammation, and lighten patches of darker skin |
| Antioxidant | Strengthens the skin’s barrier function to lock in moisture and boost suppleness |
SPF 30+ sunscreen is necessary daily to accompany an ageing skin formula.
Visible results may show after 1 week, but lasting results take 8 weeks or longer. It is important to be patient and follow your treatment plan.
For more information on Monderma's ingredients, directions for use, safety information, storage, potential side effects, and reporting, please refer to our information leaflet.
Cumulative damage from both intrinsic and extrinsic factors means the skin undergoes a series of changes.
Visible changes include:
| Complication | Description |
|---|---|
| Fine Lines & Wrinkles | Dynamic wrinkles, like frown lines, crow’s feet, and laugh lines, appear with facial movement from repeated expressions. Static wrinkles, such as forehead and marionette lines, remain even when the face is at rest. Gravitational wrinkles, including jowls and neck wrinkles, form as ageing skin loses elasticity and sags. Atrophic wrinkles are fine lines caused by thinning and reduced skin elasticity. Compression wrinkles, like sleep lines, develop from prolonged external pressure |
| Thinning & Fragility | Thinning skin becomes more fragile as the dermis (middle layer) and epidermis (outer layer) lose protective cushioning, making it prone to wounds, tears, and bruising. Slower healing from impaired cell regeneration and a weakened vascular network increases infection risk. Additionally, fat loss beneath the skin reduces volume, leading to a hollowed appearance around the temples and cheeks |
| Dull Skin | Dull skin is an early sign of ageing, caused by slower cell turnover and dead cell buildup, leading to a lacklustre complexion. Reduced blood flow limits oxygen and nutrients, further diminishing skin’s radiance. With less light reflection, ageing skin appears matte and flat, making pores and pigmentation more visible |
| Dry Skin | Dry skin is common with ageing as moisture retention and oil production decline. Sebaceous glands become less active, reducing the protective lipid barrier, while decreased hyaluronic acid leads to moisture loss. This causes rough, flaky skin that may feel itchy and irritated |
| Hyperpigmentation | Hyperpigmentation in ageing skin is caused by slower cell turnover, hormonal changes, inflammation, and accumulated sun damage. As the skin's renewal process slows, dark spots and uneven pigmentation become more noticeable |
| Rosacea | Rosacea becomes more likely as the skin ages, due to increased visibility of blood vessels, making them more prone to dilation and damage. The skin's reduced ability to repair and manage inflammation also heightens the risk of developing rosacea or worsening redness and sensitivity |
| Psychosocial | Psychosocial factors related to early physical changes and societal attitudes toward ageing can affect self-esteem, especially in people in their 30's and 40's |
Ageing skin requires topical management to maintain resilience and overall wellbeing.